Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF- B activation
نویسندگان
چکیده
Venkatapuram Seenu Reddy, Sumanth D. Prabhu, Srinivas Mummidi, Anthony J. Valente, Balachandar Venkatesan, Prakashsrinivasan Shanmugam, Patrice Delafontaine, and Bysani Chandrasekar Cardiothoracic Surgery, University of Texas Health Science Center, San Antonio, Texas; Institute of Molecular Cardiology, Department of Medicine, University of Louisville, and Medical Service, Louisville Veterans Affairs Medical Center, Louisville, Kentucky; Department of Medicine, University of Texas Health Science Center, San Antonio, Texas; and Research Service, Southeast Louisiana Veterans Health Care System, and Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana
منابع مشابه
Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation.
IL-18 and the extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN) stimulate the expression of proinflammatory cytokines and MMPs and are elevated in myocardial hypertrophy, remodeling, and failure. Here, we report several novel findings in primary cardiomyocytes treated with IL-18. First, IL-18 activated multiple transcription factors, including NF-κB (p50 and p65), activator protein...
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